Head of High-Throughput Sequencing

The Pirbright Institute

The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats. This important research would not be possible without the proportionate use of animals, which are integral to the development of new disease control measures such as vaccines and diagnostics. We have an establishment-wide commitment to the 3Rs (replacement, reduction and refinement), high standards of animal welfare, a culture of care and openness.

Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute’s aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a ‘one Institute’ approach.

Organisation position and purpose

The activities of the High-Throughput Sequencing (HTS) Science Technology Platform (STP) are central to delivering high-impact genomics research at The Pirbright Institute. Established in 2018, the STP plays a major role in executing both small and large-scale genomics projects at the institute. We are located within state-of-the-art SAPO4 high-containment facilities in the Plowright building and provide bespoke, targeted assistance to users. The team works closely with numerous research groups at Pirbright and supports WOAH/FAO reference laboratory pathogen surveillance duties.

The unit owns and operates Illumina and Nanopore sequencing platforms, alongside liquid handling robots (Hamilton and Mosquito HV) and single-cell equipment (10X). The STP lead role will provide leadership across sequencing platform activities and contribute strategically to oversight committees, with a strong emphasis on identifying, evaluating, and implementing emerging technologies in sequencing and adjacent fields to maintain and advance the platform’s capabilities. The position will oversee key duties including (but not limited to) unit management, technical troubleshooting, and maintenance of sequencing equipment and robotic liquid handlers. Candidates are encouraged to use the flexibility of the role to pursue their own research interests, where appropriate.

Main duties and responsibility

• Manage the sequencing team and contribute to its day-to-day operations, ensuring smooth operation and delivery of the STP.
• Design, evaluate, and implement high-throughput sequencing workflows for genomics, covering short- and long-read technologies and lab automation systems; including situations of outbreak management.
• Ensure quality control, data integrity, and reproducibility across all stages of genomics workflows.
• Work routinely within SAPO4 high-containment facilities, ensuring strict adherence to safety and biosecurity protocol.
• Coordinate closely with the Bioinformatics STP to facilitate transfer of data for analysis, interpretation and archiving.
• Provide scientific and technical insight to support genomics needs across research groups to ensure the delivery of Pirbright’s Science Strategy.
• Keep abreast of technological advances and recommend adoption of relevant new platforms or technologies.
• Serve on relevant committees and provide strategic input on genomics, shaping STP activities and institute-wide scientific priorities.                                                                                  

This job description is only an outline of the tasks, responsibilities and outcomes required of the role. The jobholder will carry out any other duties as may be reasonably required by his/her line manager. The job description and personal specification may be reviewed on an ongoing basis in accordance with the changing needs of The Pirbright Institute.

Specific requirements

Essential

• PhD in Genomics, Molecular Biology, Virology, or a related field, or equivalent industrial experience.
• Track record and/or documented experience in genomics and sequencing technologies.
• Demonstrated expertise in developing and troubleshooting NGS workflows, including both library prep and sequencing protocols.
• Documented experience with Illumina and Oxford Nanopore Technologies platforms.
• Leadership capabilities with prior experience managing laboratory personnel and projects of medium to large scale, ideally involving external collaborations or significant funding.
• Excellent organizational, problem-solving, and communication skills.

Desirable

• Experience in implementing and operating lab automation platforms (e.g., liquid handlers, robotic systems).
• Proficiency in basic bioinformatics and data analysis, with the ability to build or oversee construction of data processing pipelines.
• Experience in single cell sequencing and/ or spatial transcriptomics technologies.
• Familiarity with quality management systems and working in high containment.
• Strong interest in cross-disciplinary collaboration.

Due to the nature of the work carried out by Pirbright, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances.

What we offer

• Generous Group Personal Pension Scheme and life cover (subject to age and earnings)
• 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days
• Buy and sell annual leave
• Option to carry over up to two weeks annual leave
• Pirbright gym with subsidised membership
• Pirbright social club
• Pirbright Lifestyle Hub (employee discount site)
• Cycle to work
• Subsidised staff restaurant
• Childcare allowance
• Free onsite parking
• Electric Car charging facilities